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Home / Drugs / Starting with U / Urofollitropin

Human follicle stimulating hormone (FSH) preparation of recombinant DNA origin, which consists of two non-covalently linked, non-identical glycoproteins designated as the alpha- and beta- subunits. The alpha- and beta- subunits have 92 and 111 amino acids
CategoriesFertility Agents
ManufacturersSerono laboratories inc
Ferring pharmaceuticals inc
PackagersCardinal Health
Draxis Specialty Pharmaceuticals Inc.
Ferring Pharmaceuticals Inc.
Instituto Massone SA
Merck Serono SPA
North America Genescience LLC
Organon Pharmaceuticals
Serono SA
Vetter Pharma Fertigung GmbH and Co. KG
SynonymsFollicle-stimulating hormone beta subunit
Follitropin beta chain precursor


For treatment of female infertility


Used for the treatment of female infertility, urofollitropin or follicle stimulating hormone (FSH) stimulates ovarian follicular growth in women who do not have primary ovarian failure. FSH, the active component of urofollitropin is the primary hormone responsible for follicular recruitment and development.

mechanism of action

FSH binds to the follicle stimulating hormone receptor which is a G-coupled transmembrane receptor. Binding of the FSH to its receptor seems to induce phosphorylation and activation of the PI3K (Phosphatidylinositol-3-kinase) and Akt signaling pathway, which is known to regulate many other metabolic and related survival/maturation functions in cells.