One way to resolve this problem is to define «reliable bioavailability» as positive bioavailability results (an absorption meeting a predefined criteria) that include 84% of the trial subjects and «universal bioavailability» as those that include 98% of the trial subjects. This reliable-universal framework would improve communications with physicians and consumers such that, if it were included on products labels for example, make educated choices as to the benefits of a formulation for them directly. In addition, the reliable-universal framework is similar to the construction of confidence intervals, which statisticians have long offered as one potential solution for dealing with small samples, violations of statistical assumptions or large standard deviations.